Orexin Receptor (OX Receptor) Agonist

Orexin Receptor (OX Receptor) Agonists (33):

Cat. No.	Product Name	Effect	Purity

HY-106224

Orexin A (human, rat, mouse)	Agonist	99.93%
Orexin A (human, rat, mouse) (Hypocretin-1 (human, rat, mouse)), a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A (human, rat, mouse) binds and activates two types of G protein-coupled receptors, the orexin-1 receptor (OX1R) and the orexin-2 receptor (OX2R). Orexin A (human, rat, mouse) has a role in the regulation of feeding behavior. Orexin A (human, rat, mouse) is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats.

HY-106224B

Orexin A (human, rat, mouse) (acetate)	Agonist	99.93%
Orexin A (Hypocretin-1) (human, rat, mouse) acetate is a hypothalamic neuropeptide with analgesic properties (crosses the blood-brain barrier). Orexin A (human, rat, mouse) acetate binds and activates two types of G protein-coupled receptors, the orexin-1 receptor (OX1R) and the orexin-2 receptor (OX2R). Orexin A (human, rat, mouse) acetate can be used in studies of appetite regulation, neurodegenerative diseases and modulation of injurious messaging.

HY-P1339B

Orexin B, human acetate	Agonist	99.68%
Orexin B, human acetate is the acetate form of Orexin B, human (HY-P1339). Orexin B, human acetate is the agonist for Orexin Receptor, with K_i of 420 nM and 36 nM for OX1 and OX2. Orexin B, human acetate participates in the regulation of appetite, wakefulness, cardiovascular function and neuroendocrine.

HY-171032

(R)-YNT-3708	Agonist	99.07%
(R)-YNT-3708 is a selective orexin 1 (OX₁R) agonist, with an EC₅₀ of 7.48 nM. (R)-YNT-3708 has antinociceptive effects.

HY-171032A

(S)-YNT-3708	Agonist	99.80%
(S)-YNT-3708, the S-enantiomer of YNT-3708, with low activity for OX1R and OX2R (EC₅₀ = 3595 nM and 1661 nm, respectively).

HY-136181

YNT-185 dihydrochloride	Agonist	99.78%
YNT-185 dihydrochloride is a nonpeptide, selective orexin type-2 receptor (OX2R) agonist, with EC₅₀s of 0.028 and 2.75 μM for OX2R and OX1R, respectively. YNT-185 dihydrochloride ameliorates narcolepsy-cataplexy symptoms in mouse models.

HY-P1339A

Orexin B, human TFA	Agonist	99.16%
Orexin B, human (TFA) is an endogenous agonist at Orexin receptor with K_is of 420 and 36 nM for OX1 and OX2, respectively.

HY-106224A

Orexin A (human, rat, mouse) (TFA)	Agonist
Orexin A (human, rat, mouse) (Hypocretin-1 (human, rat, mouse)) TFA, a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A (human, rat, mouse) TFA binds and activates two types of G protein-coupled receptors, the orexin-1 receptor (OX1R) and the orexin-2 receptor (OX2R). Orexin A (human, rat, mouse) TFA has a role in the regulation of feeding behavior. Orexin A (human, rat, mouse) TFA is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats.

HY-P1341

OXA(17-33)	Agonist
OXA(17-33) is a potent and selective orexin-1 receptor (OX1) agonist. OXA(17-33) shows a ∼23-fold selectivity for the OX1 (EC₅₀=8.29 nM) over OX2 (187 nM).

HY-154789

RTIOXA-43	Agonist	99.94%
RTIOXA-43 is a orexin receptor agonist with EC₅₀s of 24 nM and 24 nM for OX2 and OX1 receptors, respectively.

HY-19320

Orexin 2 Receptor Agonist	Agonist	99.59%
Orexin 2 Receptor Agonist is a potent selective OX2R agonist with an EC₅₀ of 23 nM.

HY-136181A

YNT-185	Agonist	98.36%
YNT-185 is a nonpeptide, selective orexin type-2 receptor (OX2R) agonist, with EC₅₀s of 0.028 and 2.75 μM for OX2R and OX1R, respectively. YNT-185 ameliorates narcolepsy-cataplexy symptoms in mouse models.

HY-137440

Firazorexton	Agonist	99.94%
Firazorexton (TAK-994 free base) is an orally active and brain-penetrant orexin type 2 receptor (OX2R) selective agonist. Firazorexton (TAK-994 free base) can promote wakefulness and has the potential to improve narcolepsy-like symptoms in mice.

HY-137440A

Firazorexton hydrate	Agonist	99.94%
Firazorexton hydrate (TAK-994) is an orally active and brain-penetrant orexin type 2 receptor (OX2R) selective agonist. Firazorexton hydrate can promote wakefulness and has the potential to improve narcolepsy-like symptoms in mice.

HY-P1340

[Ala11,D-Leu15]-Orexin B(human)	Agonist	98.31%
[Ala11,D-Leu15]-Orexin B(human) is a potent and selective orexin-2 receptor (OX2) agonist. [Ala11,D-Leu15]-Orexin B(human) shows a 400-fold selectivity for the OX2 (EC₅₀=0.13 nM) over OX1 (52 nM).

HY-P1349

Orexin B, rat, mouse	Agonist
Orexin B, rat, mouse (Rat orexin B) is an endogenous agonist at Orexin receptor with K_is of 420 and 36 nM for OX1 and OX2, respectively.

HY-P1349A

Orexin B, rat, mouse TFA	Agonist
Orexin B, rat, mouse (Rat orexin B) TFA is an endogenous orexin receptor agonist. Orexin B, rat, mouse TFA binds and activates two closely related orphan G protein-coupled receptors OX1-R and OX2-R. Orexin B, rat, mouse TFA stimulates food intake and energy expenditure and plays a significant role in sleep-wakefulness regulation.

HY-138695

Orexin 2 Receptor Agonist 2	Agonist	98.06%
Orexin 2 Receptor Agonist 2 is a selective orexin 2 receptor agonist, extracted from patent WO2017135306A1, example 16.

HY-159835

Oveporexton	Agonist
Oveporexton (TAK-861) is an orally active and selective OX2R agonist with an EC₅₀ of 2.5 nM. Oveporexton ameliorates narcolepsy-like phenotypes.

HY-137452

Suntinorexton	Agonist	98.66%
Suntinorexton is an OX2R agonist. Suntinorexton is used to study respiratory function during sleep.

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