Orexin Receptor (OX Receptor) Agonist

Orexin Receptor (OX Receptor) Agonists (38):

Cat. No.	Product Name	Effect	Purity

HY-106224

Orexin A (human, rat, mouse)	Agonist	99.93%
Orexin A (human, rat, mouse) (Hypocretin-1 (human, rat, mouse)), a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A (human, rat, mouse) binds and activates two types of G protein-coupled receptors, the orexin-1 receptor (OX1R) and the orexin-2 receptor (OX2R). Orexin A (human, rat, mouse) has a role in the regulation of feeding behavior. Orexin A (human, rat, mouse) is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats.

HY-106224B

Orexin A (human, rat, mouse) acetate	Agonist	99.93%
Orexin A (Hypocretin-1) (human, rat, mouse) acetate is a hypothalamic neuropeptide with analgesic properties (crosses the blood-brain barrier). Orexin A (human, rat, mouse) acetate binds and activates two types of G protein-coupled receptors, the orexin-1 receptor (OX1R) and the orexin-2 receptor (OX2R). Orexin A (human, rat, mouse) acetate can be used in studies of appetite regulation, neurodegenerative diseases and modulation of injurious messaging.

HY-177073

Cleminorexton	Agonist
Cleminorexton (Compound 67A) is an agonist of orexin-2 receptor (OX2R). Cleminorexton can be studied in research for narcolepsy and other disorders related to orexin insufficiency and/or excessive sleepness.

HY-P1339A

Orexin B, human TFA	Agonist
Orexin B, human (TFA) is an endogenous agonist at Orexin receptor with K_is of 420 and 36 nM for OX1 and OX2, respectively.

HY-154789

RTIOXA-43	Agonist	99.94%
RTIOXA-43 is a orexin receptor agonist with EC₅₀s of 24 nM and 24 nM for OX2 and OX1 receptors, respectively.

HY-P1341

OXA(17-33)	Agonist
OXA(17-33) is a potent and selective orexin-1 receptor (OX1) agonist. OXA(17-33) shows a ∼23-fold selectivity for the OX1 (EC₅₀=8.29 nM) over OX2 (187 nM).

HY-19320

Orexin 2 Receptor Agonist	Agonist	99.59%
Orexin 2 Receptor Agonist is a potent selective OX2R agonist with an EC₅₀ of 23 nM.

HY-136181

YNT-185 dihydrochloride	Agonist	99.78%
YNT-185 dihydrochloride is a nonpeptide, selective orexin type-2 receptor (OX2R) agonist, with EC₅₀s of 0.028 and 2.75 μM for OX2R and OX1R, respectively. YNT-185 dihydrochloride ameliorates narcolepsy-cataplexy symptoms in mouse models.

HY-106224A

Orexin A (human, rat, mouse) (TFA)	Agonist
Orexin A (human, rat, mouse) (Hypocretin-1 (human, rat, mouse)) TFA, a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A (human, rat, mouse) TFA binds and activates two types of G protein-coupled receptors, the orexin-1 receptor (OX1R) and the orexin-2 receptor (OX2R). Orexin A (human, rat, mouse) TFA has a role in the regulation of feeding behavior. Orexin A (human, rat, mouse) TFA is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats.

HY-136181A

YNT-185	Agonist	98.46%
YNT-185 is a nonpeptide, selective orexin type-2 receptor (OX2R) agonist, with EC₅₀s of 0.028 and 2.75 μM for OX2R and OX1R, respectively. YNT-185 ameliorates narcolepsy-cataplexy symptoms in mouse models.

HY-P99249

Vonlerolizumab	Agonist	99.70%
Vonlerolizumab (Pogalizumab; MOXR 0916) is a humanized IgG1 monoclonal antibody targeting OX40 (CD134). Pogalizumab partially blocks the interaction between OX40 and its natural ligand OX40L upon binding, thereby activating the NF-κB signaling pathway. Pogalizumab enhances T cell activation and proliferation and has shown antitumor activity in mouse models.

HY-P1339B

Orexin B, human acetate	Agonist	99.68%
Orexin B, human acetate is the acetate form of Orexin B, human (HY-P1339). Orexin B, human acetate is the agonist for Orexin Receptor, with K_i of 420 nM and 36 nM for OX1 and OX2. Orexin B, human acetate participates in the regulation of appetite, wakefulness, cardiovascular function and neuroendocrine.

HY-P1349

Orexin B, rat, mouse	Agonist	99.66%
Orexin B, rat, mouse (Rat orexin B) is an endogenous agonist at Orexin receptor with K_is of 420 and 36 nM for OX1 and OX2, respectively.

HY-137440

Firazorexton	Agonist	99.94%
Firazorexton (TAK-994 free base) is an orally active and brain-penetrant orexin type 2 receptor (OX2R) selective agonist. Firazorexton (TAK-994 free base) can promote wakefulness and has the potential to improve narcolepsy-like symptoms in mice.

HY-159835

Oveporexton	Agonist	99.68%
Oveporexton (TAK-861) is an orally active and selective orexin receptor 2 (OX2R) agonist with an EC₅₀ of 2.5 nM. Oveporexton exhibits 3000-fold selectivity for OX2R over OX1R. Oveporexton can be used for the study of hypersomnia disorders including narcolepsy.

HY-171032

(R)-YNT-3708	Agonist	99.07%
(R)-YNT-3708 is a selective orexin 1 (OX₁R) agonist, with an EC₅₀ of 7.48 nM. (R)-YNT-3708 has antinociceptive effects.

HY-P1340

[Ala11,D-Leu15]-Orexin B(human)	Agonist	98.31%
[Ala11,D-Leu15]-Orexin B(human) is a potent and selective orexin-2 receptor (OX2) agonist. [Ala11,D-Leu15]-Orexin B(human) shows a 400-fold selectivity for the OX2 (EC₅₀=0.13 nM) over OX1 (52 nM).

HY-137440A

Firazorexton hydrate	Agonist	99.94%
Firazorexton hydrate (TAK-994) is an orally active and brain-penetrant orexin type 2 receptor (OX2R) selective agonist. Firazorexton hydrate can promote wakefulness and has the potential to improve narcolepsy-like symptoms in mice.

HY-137452

Suntinorexton	Agonist	98.66%
Suntinorexton is an OX2R agonist. Suntinorexton is used to study respiratory function during sleep.

HY-172412

Alixorexton	Agonist
Alixorexton (ALKS 2680) is the orally active, selective agonist for orexin-2 receptor and can be used for obesity and hypersomnias research. Alixorexton can cross blood-brain barrier.

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